Interestingly, in our in vitro studies, increasing or decreasing the expression level of ANG2 did not affect cell growth or apoptosis (Figure 2), whereas the regulation of ANG2 expression in vivo resulted in significant changes in the growth of tumor tissues (Figure 4a and b), suggesting that the regulatory effects of ANG2 on tumor cells may depend on the in vivo microenvironment. The gene discussed is ANGPT2; the disease is neoplasm.