As shown in Figure 4a and b, compared with the tumor groups induced by TCA8113 mock cells and NC siRNA-transfected cells, the ANG2-overexpressing cells exhibited a significant increase in tumor volume (P<0.05), whereas a significantly reduced tumor volume was observed in the groups in which ANG2 was inhibited (P<0.05), revealing a positive correlation between ANG2 and the formation of tumor tissues. Here, ANGPT2 is linked to neoplasm.