CCR5 and colitis: While the data we report strongly support a role for CCR5 in rodent colitis, CCR5 gene mutations do not overtly modulate human IBD phenotypes, as demonstrated by the fact thata common 32-bp ‘loss-of-function’ deletion (Δ32) of CCR5 fails to confer protection against IBD28, 29, 30, 31, 32, 33.