Firstly, IL-6 cannot induce reactivation of virus from latently infected monocytes, only from differentiated immature monocyte-derived DCs66 and, secondly, the levels of IL-6 induced upon latent infection of monocytes with miR-UL148D deletion virus (which is in the picogram range in our analyses) is far below the levels of exogenous IL-6 (in the nanogram range) required to reactivate virus from immature monocyte-derived DCs66. Here, IL6 is linked to disease arising from reactivation of latent virus.