CFTR and intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency: Some of these manifestations have a direct causal relation to the malfunction of the CFTR in epithelial cells of gastrointestinal tract and pancreas, such as the distal intestinal obstruction syndrome and meconium ileus, whereas others, such as fibrosing colonopathy and gastritis, are regarded as secondary complications of the disease or its therapy24.