CFTR and exocrine pancreatic insufficiency: As CFTR is responsible for anion transport58, 59, its dysfunction causes abnormal water and electrolyte secretion resulting not only in thick and adherent fluids in the intestines but also in the development of mucous and acidic enzyme secretions in the pancreas causing destruction of pancreatic tissue with ensuing exocrine pancreatic insufficiency leading on its turn to malabsorption in the gastrointestinal tract57, 60.