NFKB1 and pulmonary arterial hypertension: There exhibited significant overproduction of CF6 in the lung tissues and elevation in circulating CF6 among PAH rats of MCT models and MCT plus pneumonectomy models, most likely due to mechanical stress secondary to the elevated pulmonary pressure and the inflammation activation induced by MCT, such as NF-kB activation and TNF-α releasing [7, 31, 32].