S6K1 inhibition by PF-4708671 was shown to sensitize resistant colorectal cancer cells to selumetinib [47], to decrease cell migration and invasion of MDA-MB-231 human breast cancer cell line [48] and to inhibit cell invasion and proliferation in human lung cancer cell lines and tumorigenesis in Nude mice [49]. The gene discussed is RPS6KB1; the disease is colorectal cancer.