STAT3 and autosomal dominant polycystic kidney disease: To determine whether the early (i.e. in the first hour; see Fig. 4A) or late (after 1 h; see Fig. 4B) activation of STAT3 during macrophage programming was important for the acquisition of a pro-proliferative macrophage phenotype, Stattic was incubated with THP-1 macrophages starting at 1 h after the addition of ADPKD-CM.