Providing further evidence of STAT3 activation in these cells was the observation that ADPKD-CM-mediated programming also significantly upregulated expression of Socs3 (Fig. S3), an important downstream target of the IL-10–STAT3 pathway that is known to mediate many of the regulatory and inflammatory properties of IL-10 (Yin et al., 2015). This evidence concerns the gene SOCS3 and autosomal dominant polycystic kidney disease.