FUCA2 and fucosidosis: One putative relevant modifier for fucosidosis could be α-L-fucosidase 2, which might represent a second lysosomal fucosidase, as described recently upon analysis of the lysosomal proteome (Lübke et al., 2009) and as further characterized with localization studies using mCherry-fusion constructs (Huang et al., 2014).