FUCA1 and urinary system disorder: However, at 6 months of age, the urinary bladders of Fuca1-deficient mice, particularly of male mice, were enormously increased in size with an overall volume of 2-3 ml instead of 0.15-0.25 ml in the wild type, suggesting urological problems like urethral stricture or obstruction of the bladder neck because urinary creatinine concentrations of knockout mice (n=4) were comparable to wild-type (n=4) values ranging from 68 to 95 mg/dL.