HGSNAT-deficient males (MPSIIIC males) showed behavioral alterations that reproduced the observations we and others have previously reported in two other mouse models of Sanfilippo disease, MPSIIIA and MPSIIIB mice (Fu et al., 2007; Haurigot et al., 2013; Hemsley and Hopwood, 2005; Hemsley et al., 2009; Lau et al., 2008; Li et al., 1999; Ribera et al., 2015). This evidence concerns the gene NAGLU and mucopolysaccharidosis type 3.