TH and cancer: For instance, excessive estrogen or progesterone is reported to promote cellular growth of breast and prostate tumors, with antiestrogen and progesterone currently used as the main treatment strategies for these cancer types.1, 2 Thyroid hormones (TH), mainly 3,3′-5-tri-iodo-L-thyronine (T3), are potent mediators of multiple physiological activities, including cellular differentiation, metabolic rate, digestive functions and lipid metabolism.3, 4 The actions of T3 are executed via binding to thyroid hormone receptor (TR) located in the nucleus.