TRs are ligand-dependent transcription factors encoded by two genes, TRα and TRβ. Upon binding of T3, TRs release associated co-repressors and recruit transcriptional co-activators to initiate target gene transcription.5 Liver is one of the major target organs of T3, and body TH levels are closely correlated with multiple liver-associated diseases, such as hepatocellular carcinoma (HCC).6, 7, 8, 9. This evidence concerns the gene THRB and hepatocellular carcinoma.