EVA1A and esophageal cancer: EVA1A expression is decreased in many types of human tumors, such as gastric cancer, esophagus cancer, adrenal cortical carcinoma, pituitary adenoma and parathyroid adenoma.22, 23In vivo and in vitro experiments have demonstrated that EVA1A overexpression inhibits the proliferation of tumor cells and induces both autophagy and apoptosis even under nutrient-rich conditions, and the appearance of autophagy usually precedes cell death.