CD4 and cancer: Autophagy in immune cells affects their development and function.26 Autophagosome from damaged cell could act as immune response inducer also.27 Earlier, we demonstrate that drug derived autophagosome-DRibbles induced activation and maturation of DCs, antigen cross-presentation, and T-cell activation of CD4+ and CD8+ memory T cells.9 Here, we demonstrated that autophagy was critically involved in the transfer of antigens from antigen donor cells into DCs and secretory autophagosomes can serve as efficient antigen carriers and vaccines for immunotherapy of cancers.