To examine the relevance of physical interaction between BRCA2 and PALB2 on the tumor suppressor function of BRCA2, we generated a cohort of control (wild-type and Brca2Ko/+), Brca2G25R/+, Brca2G25R/G25R, and Brca2G25R/Ko animals and monitored their tumor free survival for 2 yrs. This evidence concerns the gene BRCA2 and neoplasm.