TP53 and neoplasm: The most striking phenotype in this present study is the high tumor incidence in Brca2G25R/Ko as well as Brca2G25R/Ko;Palb2Ko/+ mice with wild-type Trp53. Sixty-nine percent of Brca2G25R/Ko and 100% of Brca2G25R/Ko;Palb2Ko/+ mice developed tumors, with an average latency of 82 and 24 weeks, respectively.