EIF4E and viral infectious disease: It has been shown that the potyviral VPg interacts directly with pvr2/eIF4E1 in yeast two-hybrid and in vitro binding assays, and the physical interaction between pvr2/eIF4E1 and the virus VPg is required for virus infection [46–49], although the exact role in the potyvirus life cycle of eIF4E-VPg interaction remains a matter of discussion [15,50].