Some genes implicated by the top 300 SNPs from maternal GWAS in labor-initiated deliveries could be comfortably assigned to these processes: infection/inflammation (NFKB1, TLR4, IRF8, ABCA1, TREML2, MEFV, WNT5A, NFKBIA), placental insufficiency (ENG, TOR2A, IGF2, KCNQ3, GNB3, LEFTY2, ARHGEF11, WNT4, WNT5A), cervical insufficiency (MMP9, TIMP2), and hormonal imbalance (WNT4, OPRM1, SP3). The gene discussed is TIMP2; the disease is placental insufficiency.