Some genes implicated by the top 300 SNPs from maternal GWAS in labor-initiated deliveries could be comfortably assigned to these processes: infection/inflammation (NFKB1, TLR4, IRF8, ABCA1, TREML2, MEFV, WNT5A, NFKBIA), placental insufficiency (ENG, TOR2A, IGF2, KCNQ3, GNB3, LEFTY2, ARHGEF11, WNT4, WNT5A), cervical insufficiency (MMP9, TIMP2), and hormonal imbalance (WNT4, OPRM1, SP3). This evidence concerns the gene ENG and placental insufficiency.