CASP3 and neoplasm: Although AP-1 activity can antagonize apoptosis in some tumor types such as liver tumors [40], and genes that encode Bcl2 family members have been proposed as anti-apoptotic targets regulated by the TF [41], inhibition of AP-1 by SR 11302 in HepG2 cells did not induce caspase-3 activity and it was not associated with the accumulation of dead cells.