Multiple linked signaling pathways enriched for genes known to be involved primarily in inflammation and immunity were identified by Ingenuity in network 1 “Connective tissue disorder, Immunological disease, Inflammatory disease” which had 4 central nodes—NFKB, p38, ERK1/2 and AKT, all predicted to be upregulated (Fig 3A). Here, MAPK3 is linked to connective tissue disorder.