CYP2C9 and Hypocalcemia: However, abnormalities in bone and mineral metabolism have been frequently reported in individuals receiving EIAEDs because EIAEDs may cause hypocalcemia through triggering the catabolism of vitamin D. In vitro studies demonstrated that PB induces cultured human hepatocytes to increase the mRNA of CYP2C9, CYP2C19 [197], CYP2B6, and 3A4 [199].