Concentrations of ET-1 were significantly higher in HTN 6.64 ± 5.36 pg/mL compared to PHTN 3.52 ± 2.29 pg/mL (F = 4.41, p < 0.05) and N 3.55 ± 1.78 pg/mL (F = 4.56, p < 0.05), but this difference was not observed between PHTN and N (F = 0.00, p > 0.05). Here, EDN1 is linked to hypertensive disorder.