In the dystonia mutant, the TorsinA Glu 303 – LULL1 Arg 276 charge interaction is lost, and the hydrogen-bonding network involving TorsinA Glu 302, Phe 306 and Arg312, as well as LULL1 Arg412 and Glu416 is disrupted (Figure 2A). This evidence concerns the gene TOR1A and Dystonia.