MYC and cancer: MYC is one of the most commonly deregulated oncogenes in human cancers and the mapping of multiple cancer risk loci and regions of focal amplification to MYC enhancer regions provides strong evidence that inappropriate MYC expression can result from the perturbation of long-range control (Yochum, 2011; Ahmadiyeh et al., 2010; Tuupanen et al., 2009; Pomerantz et al., 2009; Shi et al., 2013; Zhang et al., 2016; Herranz et al., 2014).