More recently, a study conducted in the general Japanese population proposed the Homeostasis Model Assessment–Adiponectin (HOMA-AD) index, a modified version of the model, which incorporates the total serum adiponectin level in the denominator of the index and, consequently, it adds an indirect measurement of adiposopathy [6], and ultimately an adjustment to the individual degree of adiposity. This evidence concerns the gene ADIPOQ and Alzheimer disease.