Among the three well-defined inhibitory KIR-HLA combinations that involve in NK cell education and maturation (2DL2/3+C1, 2DL1+C2 and 3DL1+Bw4), two (2DL2+C1/C2 and 3DL1+Bw4) were decreased in patients with VKH disease, suggesting a protective role of these inhibitory KIR-HLA combinations. The gene discussed is KIR3DL1; the disease is Vogt-Koyanagi-Harada disease.