Ocular infiltrating CD4+ T cells from DR4+ patients with VKH disease were shown to recognize self-peptides from melanocytes (tyrosinase450-462 and gp10044-59) that share high sequence homology with cytomegalovirus envelope glycoprotein H (CMV-egH290–302), suggesting that CMV infection may stimulate the production of T cells that cross-react with tyrosinase by a mechanism of molecular mimicry [65,66]. This evidence concerns the gene CD4 and cytomegalovirus infection.