For instance, B22 was associated with rapidly progressive disease in human immunodeficiency virus (HIV) infected individuals [69,70], immunological nonresponse to hepatitis B virus surface antigen [71], myelopathy due to human T-lymphotropic virus type I [72], and progression of liver injury [73] and unresponsiveness to interferon-α treatment in hepatitis C virus infection [74]. The gene discussed is NDUFB9; the disease is Myelopathy.