Although tumor growth was unaffected in animals treated with [NSIS6S]-[NSIS]5 (Fig 5A), microvessel density following evaluation of staining for murine endothelial cell marker CD31 was reduced to the levels seen in HEC-1-B tumor xenografts (Fig 5B and 5C), suggesting that FGF2-dependent angiogenesis in FGF2-B9 xenografts was effectively targeted by [NSIS6S]-[NSIS]5. The gene discussed is PECAM1; the disease is neoplasm.