To test the hypothesis that sADAM33 enhances asthma-like responses in the presence of a Th2 stimulus, we treated Ccsp/ADAM33 and STg littermate control mice with recombinant IL-13 (Supplemental Figure 8A) and found a significant increase in mRNA expression of the fibroblast-derived chemokine, Ccl11, in the sADAM33-expressing mice (Figure 7A). This evidence concerns the gene IL13 and asthma.