Restoration of it reduces ABL1 and BCR-ABL1 expression as well as cell proliferation33,55 Increases sensitivity to Imatinib in BaF3-BCR/ABL cells   40  Imatinib causes demethylation of promoter region of miR-203, which leads to low BCR-ABL gene expression and loss of proliferation capacity of leukemic cells   56  Hypermethylated gene in CML   57. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.