Reintegration of miR-144/451 or removal of Myc can sensitize Imatinib resistant cells to apoptosis.   30  MiR-30a intensifies resistance to Imatinib in CML, suppressing autophagy through down-regulation of Beclin1 and Atg5 expression. 34,44  MiR-181C targets such gene as Pbx3, Hsp90B1, Nmt2 and RAD21 that are associated with drug resistance, on the other hand, miR-181C is down-regulated in Imatinib resistant CML.   96. Here, HSP90B1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.