Recently, a few reports have been published in hematological malignancies.21,22 Due to anti-apoptotic effect of OPN in normal and malignant cells; 23-25  so, silencing of OPN that leads to elevation of sensitivity towards chemotherapeutic agents and attenuates cancer cells migration and invasion. 26,27  In this regard, based on the above mentioned, maybe CUR is probably considered choice. This evidence concerns the gene SPP1 and cancer.