In good agreement with our result, Subramaniam et al. in their research on HT-29 as a human colon cancer cell line which produce a large amount of CD44 protein showed that after CD44 silencing with siRNA, cell lines were less adhesive to hyaluronan and more susceptible to apoptosis induced by etoposide.35 This evidence concerns the gene CD44 and malignant colon neoplasm.