Eye involvement is among rare manifestations of ALD; this may be the case as ABCD1 expression in the eye is very low; in Expressed Sequence Tag (EST) profile, the proportion of “gene EST/total EST in pool” equals to 3/208840 and contains 14 transcript per million (“EST profile,”)(“EST profile,”)(“EST profile,”)(“EST profile,”)(39). This evidence concerns the gene ABCD1 and X-linked adrenoleukodystrophy.