In a recent study by Orellana et al. (2015), we reported from ex-vivo hippocampal slices that acute 2 h restraint stress in mice induces opening of astroglial Cx43 hemichannels, while chronic 10-day immobilization stress—a model used to induce depression in rodents—leads to increased opening of Cx43 hemichannels, and recruitment of astroglial Panx1 channels. This evidence concerns the gene GJA1 and depressive symptom measurement.