Compared with normal controls (median, 0.656% of CD4+IFN-γ− T cells; range, 0.286–2.640%; n = 39), the frequency of circulating Th22 cells was significantly elevated in newly-diagnosed patients with lymphoma (1.350%; 0.124–5.230%; n = 47; P = 0.0053) (Figure 2A). The gene discussed is CD4; the disease is lymphoma.