GLB1 and hepatocellular carcinoma: We next examined whether the HCC susceptibility SNP rs4678680 has an allele-specific impact on GLB1 expression using HCC tissues since it locates in a 18 kb upstream region of GLB1. As shown in Figure 1, we found that there were significantly higher GLB1 mRNA levels (mean ± SD) in HCC tissues compared to normal tissues (313.3 ± 33.93 vs. 189.9 ± 21.1; P = 0.003).