Ubiquitin and p62 (also known as sequestosome-1) are involved in protein degradation and often associate with pathological protein deposits that seem to be resistant to degradation, such as α-synuclein in Lewy bodies of patients with PD, in glial cytoplasmic inclusions in patients with MSA, and in animal models of synucleinopathies (18, 32, 33). Here, SNCA is linked to multiple system atrophy.