SQSTM1 and synucleinopathy: Ubiquitin and p62 (also known as sequestosome-1) are involved in protein degradation and often associate with pathological protein deposits that seem to be resistant to degradation, such as α-synuclein in Lewy bodies of patients with PD, in glial cytoplasmic inclusions in patients with MSA, and in animal models of synucleinopathies (18, 32, 33).