Moreover, bioluminescence imaging of all intraperitoneally inoculated mice revealed increased radiance (>2 × 106 p/s/cm2/sr) from the brains of Tg(M83+/−:Gfap-luc+/−) mice injected with α-synuclein fibrils shortly before they developed signs of neurologic disease, but there was no increased radiance from the brains of mice injected with PBS (Fig. 8E and F). Here, PGAP6 is linked to nervous system disorder.