KDM3A and cancer: Concurrent with the ability of NF-derived CDM to downregulate JMJD1a levels, cancer cells on plastic and CAF CDM expressed high levels of JMJD1a, whereas JMJD1a was downregulated on normal CDMs (TIFF and NF; Fig. 3h), further validating the ability of normal CDM to restrict proliferation by JMJD1a downregulation.