CSNK1A1 and melanoma: In contrast, activation of CK1α by pyrvinium [22] (Fig. 3b, c) or overexpression of CK1α in SbCl2 or SKMel19 melanoma cells (Fig. 3d) significantly reduced melanoma cell viability and induced apoptosis (Figs. 3b-d, Additional file 2: Figure S2C).