Although a variety of pathogenic process may be contributing to cortical thinning in ALS (neuronal death, dendritic degeneration and projection axon loss), we assessed whether this occurred in the SOD1 mice at different ages and brain regions, namely the motor cortex, the MPFC, entorhinal cortex and the somatosensory cortex. Here, SOD1 is linked to amyotrophic lateral sclerosis.