Serum tumor markers were elevated including CEA: 101 ng/mL (normal range, 0-5 ng/mL), CA19-9: 4018.2 u/L (normal range, 0- 35u/L), CYFRA21-1: 3.3 ng/mL (normal range, 0-2.0 ng/mL), but NSE: 13.8 ng/ml was in normal range (normal range, 0-14 ng/ml). This evidence concerns the gene ENO2 and neoplasm.