Moreover, a recent study on ovarian/tubal high grade serous carcinomas revealed three distinct subgroups according to p16 expression and RB1 status (i.e., p16 homogenous stain/RB1-, p16 homogenous stain/RB1+, and p16 heterogeneous stain/RB1+), which possessed clinical relevance for stage and patient outcome upon multivariate analysis [29]. Here, RB1 is linked to serous adenocarcinoma.