In vitro assays and analysis of mutant flies lacking the expression of the Drosophila BIN1 ortholog Amphiphysin have suggested that BIN1 modifies AD risk through Tau pathology [26] or β-amyloid production [27] and studies have reported altered expression of BIN1 in Alzheimer Disease, albeit with discrepancies [26, 28–31]. This evidence concerns the gene BIN1 and early-onset autosomal dominant Alzheimer disease.