CASP8 and colon carcinoma: We show here that although our newly developed ceramide analogs enhance FasL-induced caspase 8 activation and increase FasL-induced apoptosis in human colon carcinoma cells, ceramide analog IG7 apparently does not alter cIAP1 and xIAP protein levels in human colon carcinoma cells, suggesting that IG7 acts through a different mechanism from LCL85 in enhancing FasL-induced apoptosis.