GRIN2B and post-traumatic stress disorder: The unique mechanism, by which hippocampal GluN2B is training-strength-dependently involved in memory formation, suggests that GluN2B can flexibly participate in memory formation through a rapid change in its membrane expression following individual experience, and thus indicating that GluN2B within the hippocampus could be a potential target to prevent from the formation of “bad” memory, e.g., in posttraumatic stress disorder (PTSD).