Fibrillin-1 expression was detected in 85 (86.7 %) of seminomas, 78 (83.0 %) of embryonal carcinomas, 21 (95.5 %) of yolk sac tumors, 3 (17.6 %) of choriocarcinomas, 35 (71.4 %) of teratomas, 68 (97.1 %) of GCNIS and 1 (1.2 %) non-neoplastic tissue. This evidence concerns the gene FBN1 and choriocarcinoma.