IL10 and systemic lupus erythematosus: Blockade of sCTLA-4 revealed significant response differences between PBMC from healthy donors and SLE patients with only IL-10 levels increasing following PPD or peptide stimulation in the SLE patient group, suggesting that any response enhancement by blocking sCTLA-4 function is likely to reflect the predominant T-cell phenotype and the associated cytokine response, in this case IL-10.