Blockade of sCTLA-4 in the healthy donor cohort generally suppressed or did not alter cell proliferation and cytokine production (Fig. 4 and summarised in Table 2; p < 0.05, Wilcoxon), while the SLE cohort following sCTLA-4 inhibition significantly enhanced the prevailing IL-10 cytokine phenotype stimulated by the peptides. The gene discussed is IL10; the disease is systemic lupus erythematosus.