In a diet-induced obesity model in mice, the treatment with ACEinhibitor prevented PEPCK increase in the liver while no effects occurred with other RASblockers, such as aliskiren and losartan, which indicates a possible relationshipbetween ACE inhibitors and PEPCK-related pathways, as glyceroneogenesis in adipose cells(25). The gene discussed is PCK2; the disease is obesity due to melanocortin 4 receptor deficiency.