daTSSs with no GRO-cap signal in either K546 or GM12878 cells and that may be considered T47D/A1-2 specific (605 genes; 21%) show an enrichment in categories associated with breast cancer (“breast or ovarian cancer”: p-value = 1.28 x 10−5; “mammary tumor”: p-value = 2.10 x 10−5). The gene discussed is CXCL1; the disease is breast cancer.