TP53 and lung cancer: The reaction of acrolein with a guanosine analog in vitro was first described in 1984 by Chung et al.57 Since then, the damage by unsaturated aldehydes to DNA was reported in many tissues, especially in lung cells of smokers, where it was suggested to represent a major etiological agent for cigarette smoke-related lung cancer.58 A pattern of DNA damage in the p53 tumor suppressor gene produced from acrolein exposure resembles the p53 mutation patterns found in lung cancer.