In addition to these two cytokines, other markers that showed potential in the present study as determined by p-values for differences between TB and ORD or inclusion into top biosignatures, and which were also identified in the two previous saliva based studies [11,12] as diagnostic candidates including fibrinogen, A2M, CRP, IP-10, MIP-1β, IL-17, VEGF and SAP, may be strong candidates for further investigation in future larger studies. This evidence concerns the gene CRP and tuberculosis.