Studies have demonstrated that genetic ablation of Id4 in mice (Id4−/−) leads to attenuated prostate development and PIN lesions as early as 6 weeks post-partum which is associated with a pro-neoplastic phenotype (Pten-, Id1+, pAkt+, Ki67+, Nkx3.1-) [6]. The gene discussed is ID4; the disease is prostate intraepithelial neoplasia.