GFRA1 and cancer: In another study on gastric cancer metastasis, GFRA1 methylation signal was detected in 60.2% cancer tissue samples from the discovery cohort, a cutoff value for the proportion of GFRA1-methylated cells (> 26.4%) was further calculated according to ROC curve to define GFRA1 methylation-positive samples in the Kaplan-Meier survival analysis [5].