IGKV4-1 and central nervous system cancer: The data show that pFAK and pSrc expression was reduced 24–96 h upon TMZ treatment (following 48 h β3-siRNA transfection) (Figure 7A), while the expression of ILK was not changed (data not shown), indicating that integrin αVβ3 signals in glioma cells through pFAK and pSrc.