The data show that pFAK and pSrc expression was reduced 24–96 h upon TMZ treatment (following 48 h β3-siRNA transfection) (Figure 7A), while the expression of ILK was not changed (data not shown), indicating that integrin αVβ3 signals in glioma cells through pFAK and pSrc. The gene discussed is IGKV4-1; the disease is glioma.