THBS1 and neoplasm: Although the significant increase in THBS1 was not obvious in IR tumors, patients with PLN had significant increase in tumor THBS1 expression in both the post-cycle-1 and post-cycle-4 tumor specimens compared to baseline (mean THBS1 0.72 ± 0.83, 1.06 ± 0.80, 1.41 ± 0.62 for baseline, cycle 1 and cycle 4; change 46.16% and p = 0.034 for cycle 1 vs baseline; change 95.49% and p = 0.032 for cycle 4 vs baseline; Figure 3F).