High baseline THBS1 and SPARC were significantly associated with poorer OS (Figure 2A–2B), and high baseline SPARC was an independent prognostic marker in multivariate analysis (HRadjusted 3.78, 95% CI 1.03–13.92, p = 0.045), adjusted for age, tumor grade, metastasis, tumor size, pathological lymph node involvement, ER, PR and Her2 status. Here, ESR1 is linked to neoplasm.