SPARC and neoplasm: In contrast, there were no significant chemotherapy-induced tumor expression changes in FN, SPARC and α-SMA in patients without PLN involvement (mean FN 2.10 ± 0.72 vs 2.55 ± 0.76, change 20.85%, p = 0.284; mean SPARC 1.23 ± 0.86 vs 1.39 ± 0.98, change 12.70%; mean α-SMA 36.90 ± 31.80 vs 30.30 ± 25.20, change −17.89%, p = 0.205).